Saturday, March 31, 2012

Families Can Enjoy Mountain Biking Together ? Article Squadron

Mountain biking has gained popularity in recent years as it offers an opportunity to get fit, get into nature, and see the world from a new perspective. Besides, it?s one of those few sports or activities that can be enjoyed by everyone ? mother, father, brother, sister ? provided you have the right gear.

You may have seen mountain biking races on TV, but this is not the true essence of the sport. Beginners in mountain biking don?t have to head out on rough terrain ? they can start on flat surfaces until they get used to how the bike works. This may be the most feasible option anyway if you have young children with you.

A mountain bike differs from a road bike ? it is specifically built to handle tough off-road trails and the numerous obstacles that may come with it. A heavier mountain bike may be more affordable, but beware of bad handling ? keep this in mind when the time comes for you to get a bike. If you want to save some money, do so, but not with the helmet ? a good helmet can save anyone from serious head injury. And if you have children you are teaching how to ride a bike, never let them ride one unless they are wearing their own helmets.

The world is still rich in beautiful parks and nature reserves where mountain bikers can pass through on their trails. When biking with your family, start on the flat surfaces, before you start moving on to small hills ? only when you?ve gotten to know your bikes and how they work. Children can be quite adventurous though ? so watch them on the downhills!

The most important thing perhaps about a mountain biking family vacation would be the chance to see the world in a brand new light. This is even better than your usual hiking vacation, because your children won?t get bored so easily, and still be able to see the beautiful forests and wildlife scenery. Cycling in a forest is an amazing experience, and the opportunity to see wildlife up close is one your children won?t forget. And take note we?re not talking about angry predators like mountain lions, but rather the kin of Bambi and Bugs Bunny.

Many tour companies offer bike tours, and these would include mountain bike vacations for beginners, complete with food and lodging. One thing to note is that mountain bike trails are marked according to difficulty, so take this into consideration and also ask yourself how experienced you and your family think you are when it comes to mountain biking. You may eventually want to move on to the longer, harder trails once you have practiced more often and more intensely, but remember that your children may get tired easily, even if it doesn?t always look that way.

Mountain biking is a wonderful sport that the whole family can enjoy together. With that said, we leave you with four words of wisdom. No Helmet, No Ride.

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8 Incredible Advantages of Teaching Yoga

Each and every difficult occupation yields some sort of fulfillment, however the fitness experts industry had an astounding 85% job fulfillment price according to an Concept Well being & Fitness survey.

Occupation Satisfaction

In the same survey, 98% of those interviewed felt that ?My operate gives me a feeling of personal accomplishment.? Lack of personal pleasure is the most frequent cause why people leave a work. These statistics make it obvious that this is an extremely harmonious atmosphere to work in.

For many of us who worked in the corporate world and shifted into the health and health and fitness industry, the energy felt in a well being club, ashram, or wellness center is similar to being on vacation.

Theres always something to do, but the task itself is really gratifying.
Benefits of Helping Family, Friends, Students, and Co-workers
Your self esteem improves as you obtain solutions for the pain management of others, ailments, health and fitness, stress management, constructive thinking, etc.

The list goes on, as you continue your own journey of self improvement, but the feeling of gratification you get from helping someone uncover the right path, is beyond words.

You will always remember: That student who reaches their ideal physique bodyweight, the physically impaired student who finds that they, too, can live a better quality life, and the student who leaves your class without the headache or backache they came in with.

Your Own Well being

As a practitioner of Yoga, you have turn out to be more aware of your daily ups and downs. You monitor your breath, posture, moods, diet, and exercise on a daily basis.

As a Yoga teacher, you are setting an example to your students and training them to live a quality life. This path will enable you to live longer and live better.

There is no Shortage of Do the job

When the working world is in the ?9 to 5? mode, you have many opportunities with Corporate Accounts, The Health Industry, Senior Centers, Medical
Centers, Referrals, etc. This is when you to teach them, with any free time you have.

Once I became totally self-employed, there were more daytime off-site Yoga teaching opportunities than I had time for in a geographic area that has many active Yoga teachers and studios. One of my best students, who became a Yoga teacher through our on-site program, inherited an area that I could no longer service due to time restraints.

The object is to contact them. This is where your post cards occur in handy, if you dont have a personal referral.

Continuing Education

Yes, learning new things keeps your mind stimulated and healthy. You will never tire of subjects to study, explore, and investigate. There are so many facets of Yoga, that one life span, is just not enough time to learn it all.

Its not a race, but it is a journey. You will discover friends, colleagues, and students who are on the same path. This makes giving, receiving, and sharing a superb thing along the way.

Time

You will have time to stop, think, breathe, relax, or meditate. You can always fill your plate beyond its limits, but you no longer have to.

You can determine whether or not you will be stuck in traffic during rush hour. You decide what hours you will work and what days you have off. You will come to the realization that your time is your own.

Independence

Everyone wants control of their own life, but really few achieve it. Being in company for yourself, can help you control your own destiny and that of your family.

Sure there are limits to what one person can accomplish, but it is better to try than to have never tried.

Success

No matter what you want, if you publish down your short-term and long-term goals, you will make great progress toward them.

It is best to keep these goals in a place where you can see them daily and visualize yourself accomplishing your goals. You must be specific about time frames and ethical methods used to meet them. You can even use them in meditation.

Review your long-term goals at least once each and every season and every year.
Review your short-term goals daily. You will see yourself make rapid success
in this way.

Lastly, goals do not have to be material at all. For example: You may wish to start teaching Yoga in a year, and the following year, get a part-time Yoga instructing position. This form of goal setting is realistic and beneficial to mankind.

That is the important ? If you select a goal that will advantage others, you will surely achieve it.

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My blog ? Unsecured Loans: Quick Financial Help Without any ...

A lot of years back, loan providers or money establishments utilized to offer fiscal aid to men and women only in opposition to some safety. Nevertheless, it was not Monster Beats Outlet an excellent practice for the reason that tenants were not able to borrow funds. So as to assistance non-homeowners and tenants who are in financial crisis, lending businesses introduced unsecured financial loans in industry. It?s a variety of financial assistance in which people are not necessary to deposit any protection. Absence of protection isn?t going to only bring various benefits for tenants and non-home homeowners Foamposites Release Dates but also helps make the personal loan procedure rapid and speedy. Due to the fact there isn?t a situation of protection deposit, homeowners also like to make use of this financial loan assistance to satisfy distinct expenses. To put it differently, we can say that loan choice does not contain any risk for Clearance Running Shoes borrowers.

There?s a big risk for bank loan providers because they tend not to get anything to recover the bank loan amount in the event borrowers fall short to payback money. Unsecured loans can arrange quick hard cash for everyone during the range of ?500-?25000 for your time period of 1-10 a long time. Emergency Jordan 12 charges can knock the door in diverse forms, like household improvement wedding reward, vehicle purchase, debt consolidation, credit score card payment, education, travel price, holidays, business, and many others. In order to satisfy each one of these expenditures, people today want speedy financial loan service. In this sort of circumstances, this financial help plays quiet New Louis Vuitton significant role. This possibility is not going to only supply rapidly income but will also provides revenue without any risk. On account of absence of collateral, lending providers charge slightly expensive interest rate. You may effortlessly obtain better loan deal and Lebron James shoes greatest loan company with the help of net.

Several on the internet monetary companies have come in United kingdom marketplace and supplying unsecured financial loans as per the requirement and require of Cheap Gucci Outlet individuals. Together with the assist of on the net application procedure, buyers can invite number of bank loan quotes via on-line. When you receive various estimates with none obligation, you discover on your own in superior circumstance to decide on just one ideal possibility. People today can Kobe Shoes access online software type of on the net lending organizations from property or office environment. You only will need to own laptop and web link.

Eligibility requirements for getting unsecured finance Jordan 14:

- Age of the individual must be 18 years previous
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Friday, March 30, 2012

Ent Specialist Takes Care of Your Ear, Nose and Throat

In gigantic cities like the metropolis there is so much of rush in lifestyle that people are not able to take proper care of themselves. Lifestyle here is quite fast tracked and people are very busy in their lifestyle. There are workaholics people don?t even care about their health. They just know one thing and it is to work extra long hours. They are very expertise in working extra long hours. They never ever care about their health and body fitness.

When you are so careless about your health then it is obvious that you will fall ill on frequent basics. Hence, it is always suggested that people should take proper care of them and give their work, preference after their health.Our body is made up of thousands of organs, the most important one are eye, ear, nose and throat. We cannot imagine our life without these.

Among all these sense organ the organs which are interrelated are ear, nose and throat. If we have any sort of problem related to throat it will definitely affect our nose and ears also.

The most prominent example is when we have cold and cough, our throat is the first one which is affected and after that we may have a running or blocked nose. If this cough and cold increases it even start affecting our ears, in many critical cases it can even spoil our ears.Many people every year suffer from sore throat or other cold and cough related problem and ailment as there is any sort of climatic change. It is suggested to visit a physician before it becomes a serious ailment.

Generally we see that small children suffer from throat infection, running nose and blocked ears. The reason is weak immunity system.

But these problem and ailment should come to an end as the child becomes teenager; if not then the child should be properly diagnosed and treated by an ENT specialist. Otolaryngology or ENT (ear, nose and throat) is the branch of medicine and surgery that specializes in the diagnosis and treatment of ear, nose, throat, and head and neck disorders.

In places like metropolis where life is quite fast paced and every thing is moving on instant track, to keep your health in a proper condition is quite a problematic. No one have sufficient time to look after there health and fitness and immunity system. All are just busy enough to not give a single thought to there body health and fitness leave being diagnosed and getting treated by doctor. There are some good doctors available in Delhi who can diagnose and treat you such as otolaryngologists in Delhi or should say ENT doctors in Delhi. There are ENT specialists in Delhi to specifically deal with all sorts of ear problems and ailment.

Source: http://health.ezinemark.com/ent-specialist-takes-care-of-your-ear-nose-and-throat-7d352a4d16aa.html

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Thursday, March 29, 2012

asics ? Blog Archive ? griffeys shoes Relationships Commitment ...

Do you know that early experiences of abandonment conduct favor a damn exasperate than decease when one namely attempting to create a successful and healthy relationship within their developed life? Do you know namely the negative memory of abandonment remain stored deep within the subconscious mind and from there produce negative faiths virtually one?s ego such as: I?m unlovable,asics kayano 17, I?m unwanted,burberry outlet, I?m unworthy,ken griffey jr shoes, I?m defective I don?t deserve apt exist,griffeys shoes, etc.? Do you understand these negate limiting beliefs behaviour like?set points?is set you and your life aboard a self destructive lesson that namely afterward to impossible apt acquire off of unless you comprehend the hidden of how to permanently annul them? So do you paucity apt learn extra?
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Outer Banks Vacation Rentals | Travel and Leisure

North Carolina is enriched with many tourist destinations. One of the most popular place people go to would be the Outer Banks for the great weather and the coastlines. Many vacationers have often marveled at the beautiful sandy beaches and the wide variety of recreational activities to choose from. Of course there are many hotels and resorts dotted on the coastline, but the best option for a real vacation would be an Outer Banks. When you want to be more than just an ordinary tourist, a vacation rental home, cottage, apartment or condo is most suitable for you and your family. Because you rented the home from the owner, you will get wonderful accommodations for a much lower cost; especially if what you have in mind is a week-long vacation.

Vacationers long for a place where they could relax and unwind. It should be a place that offers privacy when needed. A hotel or resort stay would mean sharing some facilities with other guests. It would mean the occasional noisy lobby or hallway, some staff moving about your place of accommodation. In an Outer Banks vacation rental you do not have to deal with strangers within or near your private dwelling. You can share it with only the family or the companions you have. You have the option to do a lot of things that you might not be able to do in a hotel, like for example a barbecue or a private time at the pool.

When you have all the comforts of an Outer Banks vacation, you will have your time for peace and quiet, and you can arrange when you want to get out and have some fun. After all, part of a good vacation is the recreational activities that you share with your family or companions. It is highly recommended that you wake up early one morning during your stay and watch the sunrise. You will surely fall in love with the view. Then later on you can go swimming or get that tan you have been longing for. If you are fond of water sports, you can go surfing, kayaking, jet skiing or other water activities you would like to experience. You can take your children fishing or on dolphin cruises which they will surely enjoy. You can even just smell the clean and fresh salt air and you know you already have one great benefit from the vacation. You can go places in North Carolina. You can do the stuff vacations are made of. You can do almost anything when you got the ideal Outer Banks vacation.

Related posts:

  1. Vacation Rental Ownership
  2. Perfect Trips Start By Vacation Rentals
  3. Vacation Rentals Hawaiian Beach
  4. The Fine Print Comes To Vacation Rentals
  5. Why You Must Choose Vacation Rentals

Source: http://relaxzen.net/outer-banks-vacation-rentals.html

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Wednesday, March 28, 2012

WDW Radio Kids & Teens Day: Happy 25th Anniversary, Disney ...

By: Admin on Tuesday, March 27th, 2012


by Makena W.

The Disney Store has been around for 25 magical years. For the month of March, Disney stores all over the country have been celebrating by having activities every Saturday. Here is a recap of all the fun events.

March 3rd: Scavenger Hunt
This one was my favorite so far. Now, you might think that this sounds easy, but remember this was designed for smaller kids so, unless you were walking around on your knees, it was a challenge. You hunt around the store for signs that had a Disney character on it and a word. You would then look at your sheet and write the word next to the character pictured on the sign. In the end, you should have gotten the sentence ?Thanking you for 25 magical years.? If you deciphered this sentence and showed it to a Cast Member, you got a cute puzzle to try and put together. The puzzle is only 25 pieces, but has the 25 year drawing printed on it.

March 10th: Create-your-own Party Hat
I was unable to go to this event because my mom was done with hats (March 3rd was also Platypus Day and we made our own fedoras). I talked to a friend of mine and found out what this day?s celebration was all about. You had the opportunity to make your own classic-birthday-shaped hat and decorate it with stickers. These stickers weren?t the ones used in the ?Stickers and Story-telling event? that would take place a couple weeks later.

March 17th: Trivia Game and Dance Party
I came into this event prepared for whatever questions were going to be thrown at me. When the Disney Store celebrated Mickey Mouse?s birthday a few years back with a trivia contest, and I was the only person that day that got all 10 questions right about Mickey Mouse. Since then, my family has had a friendly rivalry against me and each other when it comes to Disney trivia. When the first question appeared (What was the name of money used in Disney parks but has been out of production since 2009? The answer was Disney Dollars) I thought I had this contest in the BAG! But then the questions got more difficult. (Which character makes a cameo appearance in Aladdin? The answer was the Beast!) My brother and I eventually tied with 3 out of 5 correct. Then came the dance party. Kim, a cast member that deserves a raise after her debut as the dance instructor, led us through games like freeze dance (when the music stops, you freeze and pose like a Disney character) and a game where you dance in slow motion when the music slows down and pick up the pace when the music speeds up. The funniest part of the day was when we had to pose like Goofy and both my brother and I struck the same pose ?? when Goofy has gum on his shoe in the Orlando International Airport! Overall, I had a fun Saturday with this event and left with both a certificate of participation (signed by my favorite cast member, Steve Y.) and a 3 inch 25 year button.

March 24th: Stickers and Story-telling
This event was the best one to express yourself. ?You got a sheet of stickers and a mad-lib style paper with plenty of area to place the stickers. Included in this blog is a picture of what I did with my stickers, and what story I created by filling in the blanks. In my Disney celebration, attended by Oswald and Peter Pan, we had chocolate cake and played pin the tail on the donkey!? This was my favorite event to watch other kids do also. Some kids refused to use certain stickers and others made sure to use every one!? I saw many things from candy-flavored cake to rainbow socks written in their stories. You could even pop out your story and keep it if you wanted to!

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March 28th: Happy Anniversary Disney Store!
This event is tomorrow, and I hope to have a ?doctor?s appointment? around the time my local Disney store opens to receive the silver hats only available Wednesday. The first 250 people to go to your local Disney store get exclusive Special Edition 25th Anniversary Mickey Ears! ?Our Disney Store cast members say that many people are telling them that they?re going to work late just so that they can get their ears.? They don?t expect them to last long! But if you can?t make it to the Disney Store early or are 251st in line, the celebrations continue all day with 1 non-stop playing video. In addition, every 20 minutes, a game will be played, including Simon Says and another dance party (maybe Kim will be back)! Also, if you visit the Disney Store at any time throughout the day, you can buy the exclusive 25th anniversary Vinylmation and get special savings in-store or online!

?

I hope you enjoyed my recap of all the anniversary celebrations continuing at the Disney Store. Remember, tomorrow is your last chance to join into the festivities!

Congratulations to Marisa who got the previous ?Where in the World? picture correct.

?

See ya REAL soon!
~Makena

Quote of the Week: ?The past can hurt, but you can either run from it or learn from it,? Rafiki, The Lion King

Makena is a 13 year old middle school student who spends much of her free time researching Disney. She enjoys sharing Disney facts and even plans Walt Disney World vacations (including searches for secrets and Hidden Mickeys) for friends and family.

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Source: http://www.wdwradio.com/2012/03/wdw-radio-kids-teens-day-happy-25th-anniversary-disney-store/

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You Be The Judge ? He Says, She Says ? By USFSB.com

HE SAYS:

My career practicing law, particularly, since it was concentrated in the area of litigation and trial work, involved a lot of writing and public speaking.?? The writing was serious, well researched, and technical works on legal issues affecting my clients and usually took the form of affidavits, memorandums of law, and briefs.? Even though the subject matter was weighty, the writing also needed to be interesting, engaging, and, most of all, persuasive.? After all, the point of it all was to convince a Judge that my client?s position was correct and that my opponent was wrong.

For me, the best part was that I would receive the ultimate critique of my efforts in the form of an Opinion or Decision from the Court.? This would let me know, in no uncertain terms, whether or not what I had written was persuasive enough and good enough to win the case for my client.? There is no greater gratification then when you have articulated your point of view well enough to persuade a Judge to decide in your favor.?? Likewise, there is no greater frustration then when you fall short and lose.

When I came to USFSB there was very little opportunity for any creative writing until I started to write my articles for USFSB?s Newsletter.? Even then the nature of our Newsletter did not lend itself to very much in the way of creativity since most of my articles were just meant to inform our Members of our products or services.

It was not until I started to write my blog postings that I finally came full circle and had the opportunity to be as creative as I wanted to be in my writing efforts and my choice of topics.? The difference, however, is that I do not get the same definitive level of feedback and, certainly, there is not the same kind of validation as I would receive when writing in my law practice.

Now, my writing goes off into the nebulous world of the Internet and there is no way of knowing, for sure, what impact it is having on those who may be reading my blog postings.?? In any event, I am having a lot of fun with this creative outlet even if I am not going to get a winning decision from a Judge.?? So, instead, you be the judge.

On Wednesday, Joe makes some observations that may have a ring of familiarity to some people in ?Sound Familiar??.?????????????

WHAT DO YOU SAY?

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Source: http://usfsbblog.wordpress.com/2012/03/26/you-be-the-judge/

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Sunday, March 25, 2012

The Best Personal Injury Lawyer May help you Win Your Situation ...

Should there be proof that the injury anyone endured was an event of negligence by another party, a personal injury lawyer should be appointed to protect you. Slip and falling incidents are one of the areas that are covered by personal injury legal guidelines.

Personal injury law expresses that one has a directly to sue an company, or government department, should the action of an of its employers behave in a way to cause car accident directly or not directly to another party while in the line of duty. In the two cases, one should prove that this action was done in the event the officer or member of staff was on duty and it occurred due to neglect. Proving this requires a fantastic lawyer that is trained with sensitive scenarios of this nature.

Slip and fall accidents most often will occur when just one slips on an elusive floor or is blocked by something inside their path and may autumn ? these two incidences may just be proven to be cases connected with negligence. The latter can be quite a typical case associated with negligence should 1 leave an object around the walking path deliberately or due to negelect. The former can be a classic case of carelessness should the building?s manager ignore placing a note informing one that the floor is slippery, or perhaps under going cleansing.

There is a legal process to be followed when filing cases of this mother nature. The first one is to notify the entity connected with an impending lawsuit above the injuries sustained through the slip and fall incident. Should the corresponding party fall to claim responsibility, then an injury lawyers will guide one by means of filing an issue. One of the reasons as to why this method should be guided through an experienced lawyer is the process of gathering and the evaluation of facts. One also demands one of the best accident barristers who will be able to use evidence gathered in pinning within the responsible party along with placing blame.

Any accident lawyer ought to be able to sieve over the defendant?s evidence and take advantage of the loop openings that might be there and widen them to create its evidence thin. Another reason as to why you should have a strong legal business presentation is the fact that the opponent might decide for your gentleman?s agreement. These dialogue should be led by a seasoned lawyer to ensure that the settlement attained upon is the most great situation for the sorry victim, as far as the client goes. These kinds of a slip and fall lawyers can be found online; making it easy for that you take a closer look at the practice that are available and check his or her profiles. They will illustrate the advocates in the firm and the degree of study, and the dating profiles will also reveal the event and number of cases like that that the firm features handled. One should in addition look at the fees priced and only go for one that is manageable as well as affordable for the sufferer, but without affecting the level of the lawyer.

Trying to find slip and fall lawyers Toronto Defense Lawyer Toronto or car accident law firms? Then contact Accident Law firms Toronto and find out precisely how their legal staff can help criminal Lawyers brampton get you the income you deserve.

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Source: http://web-mercadeo.info/the-best-personal-injury-lawyer-may-help-you-win-your-situation/

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Free Internet Hosting The Reasons You Will need This in your ...

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Friday, March 23, 2012

Understanding individual genetic variation can help predict chemotherapy side effects

Understanding individual genetic variation can help predict chemotherapy side effects [ Back to EurekAlert! ] Public release date: 22-Mar-2012
[ | E-mail | Share Share ]

Contact: Mary Rice
mary.rice@riceconseil.eu
ECCO-the European CanCer Organisation

Vienna, Austria: The largest study ever on the effect of genetic variability on the toxicity of chemotherapy in breast cancer shows that it is possible to predict which patients are most likely to suffer serious side effects, a researcher will tell the 8th European Breast Cancer Conference (EBCC-8) today (Friday). Dr. Christof Vulsteke, from the Catholic University of Leuven, Belgium, will explain how his team's research is an important step towards achieving a personalised chemotherapy regime for each patient.

The researchers examined germline DNA[1] from blood samples from 1089 breast cancer patients who were treated between 2000 and 2010 with three commonly used chemotherapy drugs (fluorouracil, epirubicin and cyclophosphamide). For each patient, the variability in the genes that are important for metabolising these three chemotherapeutic drugs was compared with the side effects experienced.

"We found that genetic variation in one gene was highly correlated with chemotherapy side effects," says Dr. Vulsteke. "Investigating this gene before starting chemotherapy would allow us to support the patient with either growth factors to increase the patient's immunity, or dose modifications, or a different chemotherapy regimen better adapted to the patient, or a combination of these."

Currently, most patients receive the standard treatment; however, the side effects they suffer can be very different, ranging from severe to very minimal reactions. Making adjustments to treatment would have a major impact on both the physical and psychological well-being of patients, and on the financial burden to society posed by chemotherapy side effects, for example, hospitalisation.

The most important side effects of chemotherapy are mainly caused by immune system depression, which can result in potentially life threatening infections. Even though patients may take every precaution to avoid contamination, the vast majority of these infections are caused by naturally occurring microorganisms in the patient's own gastrointestinal tract. Other serious side effects noted in patients receiving chemotherapy are bleeding, severe infection of the mouth mucosa, severe bowel inflammation, nausea, and vomiting with dehydration.

"Our research has brought us one step closer towards prescribing personalised chemotherapy treatment with a minimum of side effects," says Dr. Vulsteke.

The researchers now intend to look for data from other European countries in order to further validate their results. They will also continue to follow up on their own patients; currently the patients are followed up, on average, for five years.

"In 2016 we will have a very accurate assessment of the impact of genetic variation on breast cancer survival and recurrence," says Dr. Vulsteke. "Our future research will focus on other genes involved in processing the chemotherapeutic drugs that we studied, and we will also enlarge the scope of the research by including other chemotherapeutic drugs where we can hypothesise that genetic variability plays an equally important role," he will conclude.

Professor David Cameron, from the University of Edinburgh (Edinburgh, UK), and Chair of EBCC-8 said: "In the search for ways to "personalise" anti-cancer treatments, much of the focus has been on matching the treatment to the cancer. However it should not be forgotten that we also need to ensure the treatment is "matched" to the patient, and this study is an important step in this direction, potentially allowing us to ensure that standard chemotherapy can be delivered with either less severe toxicity, or perhaps to have the dose adjusted to give maximal benefit. Further studies will be needed to demonstrate that improvements in patient survival can be achieved by tailoring the actual doses along the lines that this study suggests could be possible."

###

[1] Germline DNA comes from the egg and sperm cells that join to form an embryo, and is the source of DNA for all other cells in the body

Abstract no: 415, Friday 10.30hrs, Proffered Paper session "Patient Related Factors and Responsive Therapy", Hall F1


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Understanding individual genetic variation can help predict chemotherapy side effects [ Back to EurekAlert! ] Public release date: 22-Mar-2012
[ | E-mail | Share Share ]

Contact: Mary Rice
mary.rice@riceconseil.eu
ECCO-the European CanCer Organisation

Vienna, Austria: The largest study ever on the effect of genetic variability on the toxicity of chemotherapy in breast cancer shows that it is possible to predict which patients are most likely to suffer serious side effects, a researcher will tell the 8th European Breast Cancer Conference (EBCC-8) today (Friday). Dr. Christof Vulsteke, from the Catholic University of Leuven, Belgium, will explain how his team's research is an important step towards achieving a personalised chemotherapy regime for each patient.

The researchers examined germline DNA[1] from blood samples from 1089 breast cancer patients who were treated between 2000 and 2010 with three commonly used chemotherapy drugs (fluorouracil, epirubicin and cyclophosphamide). For each patient, the variability in the genes that are important for metabolising these three chemotherapeutic drugs was compared with the side effects experienced.

"We found that genetic variation in one gene was highly correlated with chemotherapy side effects," says Dr. Vulsteke. "Investigating this gene before starting chemotherapy would allow us to support the patient with either growth factors to increase the patient's immunity, or dose modifications, or a different chemotherapy regimen better adapted to the patient, or a combination of these."

Currently, most patients receive the standard treatment; however, the side effects they suffer can be very different, ranging from severe to very minimal reactions. Making adjustments to treatment would have a major impact on both the physical and psychological well-being of patients, and on the financial burden to society posed by chemotherapy side effects, for example, hospitalisation.

The most important side effects of chemotherapy are mainly caused by immune system depression, which can result in potentially life threatening infections. Even though patients may take every precaution to avoid contamination, the vast majority of these infections are caused by naturally occurring microorganisms in the patient's own gastrointestinal tract. Other serious side effects noted in patients receiving chemotherapy are bleeding, severe infection of the mouth mucosa, severe bowel inflammation, nausea, and vomiting with dehydration.

"Our research has brought us one step closer towards prescribing personalised chemotherapy treatment with a minimum of side effects," says Dr. Vulsteke.

The researchers now intend to look for data from other European countries in order to further validate their results. They will also continue to follow up on their own patients; currently the patients are followed up, on average, for five years.

"In 2016 we will have a very accurate assessment of the impact of genetic variation on breast cancer survival and recurrence," says Dr. Vulsteke. "Our future research will focus on other genes involved in processing the chemotherapeutic drugs that we studied, and we will also enlarge the scope of the research by including other chemotherapeutic drugs where we can hypothesise that genetic variability plays an equally important role," he will conclude.

Professor David Cameron, from the University of Edinburgh (Edinburgh, UK), and Chair of EBCC-8 said: "In the search for ways to "personalise" anti-cancer treatments, much of the focus has been on matching the treatment to the cancer. However it should not be forgotten that we also need to ensure the treatment is "matched" to the patient, and this study is an important step in this direction, potentially allowing us to ensure that standard chemotherapy can be delivered with either less severe toxicity, or perhaps to have the dose adjusted to give maximal benefit. Further studies will be needed to demonstrate that improvements in patient survival can be achieved by tailoring the actual doses along the lines that this study suggests could be possible."

###

[1] Germline DNA comes from the egg and sperm cells that join to form an embryo, and is the source of DNA for all other cells in the body

Abstract no: 415, Friday 10.30hrs, Proffered Paper session "Patient Related Factors and Responsive Therapy", Hall F1


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-03/eeco-uig032212.php

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Thursday, March 22, 2012

Commercial Real Estate Loans: Approaching ... - Online Property Info

by admin on March 21, 2012

You?re searching for commercial real estate financing ? what?s the best approach to take in contacting lenders?

Commercial lending is far less standardized than getting home financing, and has a whole language of its own.?? You and the commercial loan officer will generally discuss the tenancy and income or the property, if it is rented, and the property type, before getting into the borrower?s qualifications.? The loan amount and terms you?ll obtain will vary greatly, depending on different property characteristics.

When you contact the commercial lender, try to have as much of the following information as possible available:

1)????? The sales price or estimated value of the property

2)????? The loan amount desired

3)????? The property type, including approximate age of the improvements, square footage, lot size, and in the case of apartment buildings, the number, size, and types of apartments, who pays utilities, and what the parking arrangements are.? In the case of commercial properties, the tenancy, and when leases expire.? If the building is occupied by, or being purchased by an ?owner user? type of business/borrower, try to find out what the same space would rent for on the open market.

4)????? The income, and what expenses the owner pays.?

5)????? The borrower?s credit, overall financial situation, and other properties owned.?

Lenders are interested in how much other property your borrower owns, and what, if any, experience your borrower has in managing the type of property being purchased.

6)????? If the property is owned by an LLC, Corporation, or other entity, be ready to

provide basic information about the financial standing of that entity, as well

7)????? If possible, try to find out what properties are adjacent to the subject property.? This can be helpful in identifying possible environmental concerns.? (Relating to chemical seepage from adjacent properties.)

With this information, the lender can indicate if the loan request fits their lending criteria, and if so, what other information is required.? In many cases, the loan officer will prefer to drive by the property before any more information is gathered, and sometimes before loan terms are even quoted.?

Want to get the commercial loan officer on your side right from the start?? Of course!?

Try this:? Take some digital photographs of the front, rear (if possible) and sides of the building.? Then, take a photo of what?s on either side of, across the street from, and in back of the building.? Type up a brief two page narrative description of the property and your loan request.? This gives the loan officer a simple description of the property, the? borrowers situation, and the need for financing.? You can even provide rent rolls on apartments and information about leases and expiration dates on commercial buildings.?

E-mail this information to the lender, requesting a response.? Providing this information

saves you and the lender a lot of time.?? Not only will the lender see that you know what you?re doing, you?ll get a faster, more accurate response to your request.

As you work repeatedly with the same lenders, you?ll learn what type of information they? require to consider a loan request.? Building relationships with your commercial lenders will be a great help in closing commercial loans.? You?ll find that many commercial loan officers have a significant say in the final approval of your loan request.?

Source: http://www.busheyland.com/commercial-property/commercial-real-estate-loans-approaching-the-commercial-lender.html

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Video: Kate Moss, Stella McCartney, David Gandy in 'Ab Fab' teaser

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Wednesday, March 21, 2012

Apartment Careers: Real Estate/Property Management jobs, Seattle ...

Position Title:

Vice President Construction Services/ Management

Direct Reports:

Department Name:

FLSA Status:

Inter-department Job Title:

EEO Class:

Reports To:

Regional President/RVP's

Position Summary

The Vice President of Construction Services/Management is responsible for providing construction management services within the assigned Region including working with a large variety of Clients, Investment Manager's, Business Manager's, Vendors, as well as other corporate and site staff on construction, structural & renovation projects.

Position Reports To:

Regional President and Regional Vice President

Essential Functions/Responsibilities

Prepare and present existing and new clients with proposals for upcoming Construction Management projects.

Ensure that all code requirements comply with laws and rules of the state and regulatory agencies.

Ensure that all Repair, Renovation, & Paint practices as pertains to properties in the Pinnacle Regions under the VP's supervision are in accordance with EPA rules and laws regarding Lead Based Paint.

Ensure that all applicable permits & documentation is prepared properly and filed accordingly

Ensure that corrective notices issued by an inspecting authority are complied with correctly and within the time guidelines set by the issuing authority.

Complete reports required by management within the time restraints dictated.

Maintain currently adopted editions of NEC (National Electrical Codes) and 40 CFR 745.90 (EPA's Renovation, Repair, and Painting Final Rule) and all applicable state regs Responsible for assisting in the collection of bids for capital projects as requested, and to oversee same

Provide written record of job progress, maintain up-to-date records of drawings and specification changes, shop drawings, samples, operating manuals, testing records and if necessary, job progress photos which would be delivered to the Owner upon completion or on a monthly basis.

Track all invoices & collections for Construction Management services

Responsible for an analysis of each contract and either the set up or the monitoring of the project accounting system for to date costs, payment status and cash flow.

Responsible for evaluation and assessment of maintenance budgets as requested

Responsible for bidding out of all services every 6 months to ensure best pricing

Responsible for monitoring, maintaining, and updating all paperwork required in the policy manual which pertains to on-site maintenance practices

Attend budget meetings with the Investment Manager and client.

Work alongside the Investment Manager on current and upcoming capital renovation projects.

Is available during normal business and office to discuss and advise on-site staff, Investment Manager's, Vendors, and other peers as needed on various maintenance and renovation projects.

Is available after normal business hours for major emergencies as determined by the RVP

Assist with new and lost property transitions, Due Diligence services, loss prevention strategies, and on-going site support as requested by clients, manager's, or other supervisory persons

Assist with client communication and tours as needed

Performs other duties as assigned

Education and/or Experience .

To perform this role successfully, an individual must be able to perform all essential functions satisfactorily. The requirements define the knowledge, skill, and/or ability necessary to perform the essential functions. Reasonable accommodation may be made to enable individuals with disabilities to perform the essential functions.

Degree is not mandatory but is a plus - minimum of 5-7 years construction related experience is required

Skills/Specialized Knowledge

Extensive knowledge of property maintenance, electrical, and renovation required.

Must understand the concept of value engineering

Demonstrate excellent written and verbal communication skills.

Must be able to perform basic math, and apply mathematical concepts to practical situations.

Must be able to define problems, collect data, establish facts, draw conclusions and offer viable solutions.

Must be detail oriented, and able to focus with regular or unscheduled interruptions within an office environment.

Proficiency in Word, Excel and email system communication.

Required Licenses

Must possess, or be willing to obtain an EPA (Environmental Protection Association)

Must possess, or be willing to obtain an RRP (Repair, Replace, Paint) Certification

Other Requirements

Must be able to operate a desktop computer or a laptop with comfort and ease.

Must be able to travel independently and with regularity, approximately 2 to 4 days per week or as needed within the Region.

Physical Demands

The physical demands described are representative of those that must be met by an employee to successfully perform the essential functions of the job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

This is a supervisory position and is considered moderate in physical demands. Requirements include the ability to frequently, and sometimes for long periods of time, sit, stand, climb and descend stairs, walk, extend arms and hands forward and overhead, using fingers to grasp, and carry. Must be able to bend, crouch, kneel, or stoop on occasion. Must be able to lift and carry up to 35 pounds. Must have up-close and distance vision and the ability to adjust focus.

Must use hands and fingers to hold, carry equipment, write, type, drive, sometimes for long periods, as well as other duties as assigned.

Mental Functions

Must be able to concentrate on intricate details with moderate interruption.

Must be able to understand the theories behind several of the related concepts.

Work Environment

(Important for ADA compliance and should be specific to the job itself. An example would be "Standard work environment" or "Hazards - none.")

Source: http://jobs.apartmentcareers.com/jobs/4707226/vice-president-construction-services-managementreports-to

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Home Improvement Can Be Difficult Without The Right Info

This article has been viewed 40 times.

When woodworking, always use the proper equipment to take measurements or judge whether a surface is level ? don?t rely on your eyes. Instead, use a tape measure, level and speed square so that your measurements are accurate.

You should not always listen to contractors when you are considering a major project at your home. Even well-respected contractors can turn your original project into one that?s bigger than you anticipated. Be sure to verify all the potential problems that a contractor mentions a home having.

If you are updating or improving your kitchen and will be working in the vicinity of a fireplace or gas line, it is extremely important that you shut off the gas before starting your project. The utmost care must be taken in these situations. Your vigilance can prevent a fire from starting or someone from getting injured while the home improvement work is being done.

To avoid excessive repair bills ensure storm water does not flow towards your walls. Try to make your yard slope in the direction of the street or make your downspout longer.

Putting padding on sharp ends of furniture will help prevent any accidents that your children may have. You can do this with either corner protectors or foam tape. Also, make sure that all loose wires are secure to avoid the chance that your child could be strangled by it.

When fixing up a house for re-sale, you need to deal with the outside first before working on heating and plumbing. People can?t see the inner items, but the outside of the house is easy to see, so an ugly looking exterior will turn people off.

Pooling your resources with fellow homeowners is one way to save money when you are getting into home improvement. Rather than buying expensive tools that you will only use once, try to borrow the tools from neighbors who enjoy home improvement projects. You two can also share your expertise with each other.

Research ideas for your home improvement projects before you begin. By starting early in looking for ideas regarding your home, you will be able to come across a lot of ideas before you need to decide. Your home improvement agenda will be easier to accomplish if you are not exasperated by time limitations.

If you have a very challenging home repair job, it?s best to hire a professional. Construction professionals, like contractors and designers, do not stay in business unless they have expertise that a homeowner cannot hope to match. They are skilled at what they do, but the work is grueling. Hiring a pro with a good reputation is the best way to ensure a job well done.

Apply these tips to your next home improvement project. Using the right tools, you can turn your living space into a comfortable expression of your personality and style. Not only will you save money, but you will have hours worth of enjoyment working with your hands to improve your home.

Source: http://digg3.com/home-improvement-can-be-difficult-without-the-right-info/

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Tuesday, March 20, 2012

How Einstein (Sort of) Fixed All of Physics with the Special Theory of Relativity [Video]

The Special Theory of Relativity. It's the most famous thing the most famous physicist ever did, but what makes it so special? Turns out, it helped prove that we could, uhh, move. Seriously. Here's the latest in MinutePhysics' crusade to educate the stupid, stupid world about Einstein. [MinutePhysics] More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/fa8HiCpxAto/how-einstein-fixed-all-of-physics-with-the-special-theory-of-relativity

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