Saturday, December 3, 2011

'Oz' memorabilia set to roar at auction

By Randee Dawn

Don't be afraid! Well, be afraid for your wallet, if you've got a hankering for one of the two known Cowardly Lion costumes from "The Wizard of Oz." The lion costume will be joining one pair of Dorothy's ruby slippers (as previously reported) from the film in an auction later this month, according to The Daily Mail. Each piece is expected to fetch up to $3 million.

MGM

The sale of Dorothy's red slippers and the Cowardly Lion's costume would fund a lot of round trips from Oz to Kansas.

The Cowardly Lion costume -- which is made from real lion hide -- was being preserved at the Los Angeles County Museum of Art, and is seen in the movie when the Lion meets Dorothy on the Yellow Brick Road and actor Bert Lahr sings, "If I Only Had the Nerve" and "If I Were King of the Forest."

Meanwhile the sparkly shoes, which were used by Judy Garland in the 1939 film when Dorothy clicked her heels three times to return to Kansas, are getting a private showing in New York City on Dec. 5 at the Plaza Ath?n?e before winging their way west for the auction.

The auction, to be held at The Paley Center for Media in Beverly Hills, Calif., on Dec. 15 and 16, is being coordinated by Joe Maddalena, who owns memorabilia auction house Profiles in History and who stars in the reality show "Hollywood Treasures."

Both costume and shoes will be part of a larger sale of memorabilia that will include Bela Lugosi's cape from "Dracula," the DeLorean from "Back to the Future III," Marilyn Monroe's wedding ring from her marriage to Joe DiMaggio and a Marilyn Monroe nude painting by Earl Moran.

What one piece of Hollywood memorabilia would you most like to have? Let us know in the comments.

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Source: http://entertainment.msnbc.msn.com/_news/2011/12/02/9163865-wizard-of-oz-memorabilia-set-to-roar-at-los-angeles-auction

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Democrat leaders merge religion and party (Daily Caller)

Top Democratic legislators are promising to harness religion to help them win 2012 voters, and are also declaring that the Democratic Party?s actions are the expression of their religious obligations.

?The Democrats? values and core agenda, and President Obama?s accomplishments, are reflective of the tenets and teachings and lessons of my faith as a Jewish woman? [and] no, there aren?t things that are informed by my faith than are different from the values and ideals of the Democratic Party,? said Democratic National Committee Chairwoman?Rep. Debbie Wasserman Schultz.

Wasserman Schultz and other Democrats, including Rep. James Clyburn, spoke at a Nov. 30 press event in the DNC?s headquarters intended to promote the party?s 2012 religious outreach.

When asked by The Daily Caller if the party?s blending of religion and politics is blurring distinctions between church and state, Clyburn said, ?We are in recognition of the fundamental aspect of all of the great religions ? love, the golden rule, of doing unto others as you would have be done unto you.?

A Washington Post reporter how the Democrats planned to work with black churches. In ?the African American community, the church vote is very important? [but] the support for the president may not be as strong as it was,? the Post?s reporter said.

?As we organize going forward to next year,? Clyburn responded, ?there will be be significant efforts on our part to reconnect the fundamentals of our policies to the [religious] teachings that we all learned, be it in the Old Testament or the New Testament.?

In the past, ?we were so strong in our doctrine that there ought to be a separation of church and state, that we often took it to an extreme, and I thinks that?s how we got disconnected? from voters, said Clyburn, who heads the House Democrats? Religious Outreach Committee, established after the party lost the 2004 presidential race.

?I speak with faith leaders every day, and a number of African American faith leaders,? said Rev. Derrick Harkins,?the director of faith outreach at the DNC. ?I find the issue is not a lack of enthusiasm, but the question is often raised ?How can we be effective in this election cycle???

This use of religion for political purposes ?will work with the less discerning? religious voters, said Richard Land, director of the Southern Baptist Convention?s Ethics and Religious Liberty Commission. But, he warned, ?whenever you employ religion to justify your own positions, which may or may not be biblical, it cheapens and desacrilizes religion.?

In 2006, Obama declared at a campaign rally that he started going to church after hearing a sermon from Jeremiah Wright, a controversial, politically connected, black reverend in Chicago. The sermon, Obama said, said, ??The world as it is is not the world as it has to be,? ? [and] I loved that idea in my own life because I thought that?s a philosophy I believe.? (RELATED: Obama in 2006: ?I stole? book title ?Audacity of Hope? from Rev. Wright, ?my pastor?)

In Obama?s 2011 Thanksgiving address, ?he?sidelined any reference to God, instead saying that Americans? rights to freely speak, vote, assemble and own property depends on the approval of other Americans. ?No matter how tough things are right now, we still give thanks for that most American of blessings, the chance to determine our own destiny,? he said.

Obama, however, did use biblical language to bolster the Democrats? support for entitlements: ?This sense of mutual responsibility ? the idea that I am my brother?s keeper; that I am my sister?s keeper ? has always been a part of what makes our country special,? Obama said.??If we keep that spirit alive, if we support each other, and look out for each other, and remember that we?re all in this together, then I know that we too will overcome the challenges of our time.?

?I would look at what Barack Obama?s policies and practices are, rather than what he may have or may not have mentioned,??Clyburn told TheDC.??I believe the president?s speech was very appropriate,? he continued, because,??The first Thanksgiving was all about celebrating a freedom to worship in one?s own fashion. ? They gathered to give thanks not to any one God, but to give thanks in celebration of some omnipotent, omniscient and omnipresent being.?

The meal was shared between Indians and the Pilgrims, who were members of a specific sect of English Protestants who worshiped the Christian God described in the Bible.

Speakers also caricatured Republicans? beliefs as heartless and un-Christian.

A new generation of ?values voters,? said Young Democrats of America President?Rod Snyder, ?will reject the GOP?s fend-for-yourself theology that would roll back health care benefits for younger Americans and deny quality education, all while preserving tax breaks for the wealthiest 2 percent.?

?If your philosophy is to take away from the needy in order to give to the greedy,? said Clyburn, ?that?s anathema to my Christian faith.?

Land predicted the Democrats? emphasis on religious will rise as the 2012 election gets closer. Obama?s speech ?had all kinds of religious allusions when he ran for president, but since then they?ve disappeared,? he said. ?He?s now playing golf instead of going to Church.?

All is forgiven, Meghan McCain

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Source: http://us.rd.yahoo.com/dailynews/rss/democrats/*http%3A//news.yahoo.com/s/dailycaller/20111201/pl_dailycaller/democratleadersmergereligionandparty

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Friday, December 2, 2011

Biologists deliver neutralizing antibodies that protect against HIV infection in mice

Biologists deliver neutralizing antibodies that protect against HIV infection in mice

Wednesday, November 30, 2011

Over the past year, researchers at the California Institute of Technology (Caltech), and around the world, have been studying a group of potent antibodies that have the ability to neutralize HIV in the lab; their hope is that they may learn how to create a vaccine that makes antibodies with similar properties. Now, biologists at Caltech led by Nobel Laureate David Baltimore, president emeritus and Robert Andrews Millikan Professor of Biology, have taken one step closer to that goal: they have developed a way to deliver these antibodies to mice and, in so doing, have effectively protected them from HIV infection.

This new approach to HIV prevention -- called Vectored ImmunoProphylaxis, or VIP -- is outlined in the November 30 advance online publication of the journal Nature.

Traditional efforts to develop a vaccine against HIV have been centered on designing substances that provoke an effective immune response -- either in the form of antibodies to block infection or T cells that attack infected cells. With VIP, protective antibodies are being provided up front.

"VIP has a similar effect to a vaccine, but without ever calling on the immune system to do any of the work," says Alejandro Balazs, lead author of the study and a postdoctoral scholar in Baltimore's lab. "Normally, you put an antigen or killed bacteria or something into the body, and the immune system figures out how to make an antibody against it. We've taken that whole part out of the equation."

Because mice are not sensitive to HIV, the researchers used specialized mice carrying human immune cells that are able to grow HIV. They utilized an adeno-associated virus (AAV) -- a small, harmless virus that has been useful in gene-therapy trials -- as a carrier to deliver genes that are able to specify antibody production. The AAV was injected into the leg muscle of mice, and the muscle cells then put broadly neutralizing antibodies into the animals' circulatory systems. After just a single AAV injection, the mice produced high concentrations of these antibodies for the rest of their lives, as shown by intermittent sampling of their blood. Remarkably, these antibodies protected the mice from infection when the researchers exposed them to HIV intravenously.

The team points out that the leap from mice to humans is large -- the fact that the approach works in mice does not necessarily mean it will be successful in humans. Still, the researchers believe that the large amounts of antibodies that the mice were able to produce -- coupled with the finding that a relatively small amount of antibody has proved protective in the mice -- may translate into human protection against HIV infection.

"We're not promising that we've actually solved the human problem," says Baltimore. "But the evidence for prevention in these mice is very clear."

The paper also notes that in the mouse model, VIP worked even in the face of increased exposure to HIV. To test the efficacy of the antibody, the researchers started with a virus dose of one nanogram, which was enough to infect the majority of the mice who received it. When they saw that the mice given VIP could withstand that dose, they continued to bump it up until they were challenging them with 125 nanograms of virus.

"We expected that at some dose, the antibodies would fail to protect the mice, but it never did -- even when we gave mice 100 times more HIV than would be needed to infect 7 out of 8 mice," says Balazs. "All of the exposures in this work were significantly larger than a human being would be likely to encounter."

He points out that this outcome likely had more to do with the properties of the antibody that was tested than the method, but adds that VIP is what enabled the large amount of this powerful antibody to circulate through the mice and fight the virus. Furthermore, VIP is a platform technique, meaning that as more potent neutralizing antibodies are isolated or developed for HIV or other infectious organisms, they can also be delivered using this method.

"If humans are like mice, then we have devised a way to protect against the transmission of HIV from person to person," says Baltimore. "But that is a huge if, and so the next step is to try to find out whether humans behave like mice."

He says the team is currently in the process of developing a plan to test their method in human clinical trials. The initial tests will ask whether the AAV vector can program the muscle of humans to make levels of antibody that would be expected to be protective against HIV.

"In typical vaccine studies, those inoculated usually mount an immune response -- you just don't know if it's going to work to fight the virus," explains Balazs. "In this case, because we already know that the antibodies work, my opinion is that if we can induce production of sufficient antibody in people, then the odds that VIP will be successful are actually pretty high."

###

California Institute of Technology: http://www.caltech.edu

Thanks to California Institute of Technology for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/115604/Biologists_deliver_neutralizing_antibodies_that_protect_against_HIV_infection_in_mice

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Skywatcher Snaps Photos of Stranded Russian Mars Probe (SPACE.com)

A skywatcher has photographed a troubled Russian Mars probe that remains stuck in Earth orbit three weeks after its launch.

Astrophotographer and veteran satellite spotter Ralf Vandebergh tracked Russia's Phobos-Grunt spacecraft as it passed over the southern Netherlands yesterday (Nov. 29). Using a 10-inch (25-centimeter) telescope and a video camera, he snapped a series of images at a range of about 170 miles (274 kilometers).

"It was bright in my tracking scope, I think it was clearly visible naked-eye as well with sun at -6 degrees," Vandebergh told SPACE.com in an email. "Striking was a kind of reddish-yellowish color I saw in the tracking scope."

Despite the distance, the photos capture the broad shape and structure of the probe.

"In the images, considerable detail is visible, and I checked the detail on many frames to know [for] sure it is real detail," Vandebergh added. [Photos: Russia's Mars Moon Mission]

Troubled Mars moon probe

The $163 million Phobos-Grunt probe launched Nov. 8 on a mission to grab samples of the Martian moon Phobos and return them to Earth in 2014 ("grunt" means "soil" in Russian). The spacecraft reached Earth orbit as planned, but got stranded there when its thrusters didn't fire to send it zipping toward the Red Planet.

Russia has been trying to establish contact with Phobos-Grunt for the last three weeks in an attempt to salvage the probe's mission. Those efforts have been in vain.

In a rare piece of good news, the European Space Agency announced last week that a ground station in Perth, Australia, had managed to pick up signals from the beleaguered spacecraft. Since then, however, repeated efforts to hail Phobos-Grunt ? and get it to fire its thrusters ? have failed, including another attempt yesterday.

Even if Russian officials manage to regain control of the probe, it may be too little, too late. The window to send Phobos-Grunt on to Mars, which is based on a favorable alignment between the Red Planet and Earth, may already have closed, experts say.

Coming back to Earth?

If the 14-ton probe remains incommunicado, it's doomed to a fiery death. Phobos-Grunt's orbit will decay, and it will come crashing back into Earth's atmosphere. Experts aren't sure when exactly that might happen, but some predictions point to mid-January.

The prospect of an uncontrolled Phobos-Grunt re-entry makes some observers nervous, because the spacecraft is carrying about 8 tons of toxic hydrazine fuel. However, Russian officials have said that this fuel shouldn't make it to Earth's surface.

Phobos-Grunt is also carrying a small satellite called Yinghuo 1, China's first attempt at a Mars orbiter. And the U.S.-based Planetary Society has an experiment onboard Phobos-Grunt that aims to test how journeys through deep space affect tiny organisms.

Phobos-Grunt is the 19th spacecraft Russia has launched toward Mars since 1960. None has achieved full mission success.

You can follow SPACE.com senior writer Mike Wall on Twitter: @michaeldwall. Follow SPACE.com for the latest in space science and exploration news on Twitter @Spacedotcom and on Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/space/*http%3A//news.yahoo.com/s/space/20111130/sc_space/skywatchersnapsphotosofstrandedrussianmarsprobe

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Thursday, December 1, 2011

How to Install and Configure Windows 8 Right Now [Windows 8]

With Windows 8, Microsoft is reimagining the most basic premises of personal computers. CEO Steve Ballmer recognizes the drastic changes coming in Windows 8, even calling the platform one of the biggest risks taken by the industry giant. The UI changes and fundamental paradigm shifts that Windows 8 brings to the table are making a lot of power users eager to give the platform a trial run, even in its current state as a Developer Preview. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/HvcAnQN-zjE/how-to-install-and-configure-windows-8-right-now

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Obama lawyers: Citizens targeted if at war with US (AP)

WASHINGTON ? U.S. citizens are legitimate military targets when they take up arms with al-Qaida, top national security lawyers in the Obama administration said Thursday.

The lawyers were asked at a national security conference about the CIA killing of Anwar al-Awlaki, a U.S. citizen and leading al-Qaida figure. He died in a Sept. 30 U.S. drone strike in the mountains of Yemen.

The government lawyers, CIA counsel Stephen Preston and Pentagon counsel Jeh Johnson, did not directly address the al-Awlaki case. But they said U.S. citizens don't have immunity when they're at war with the United States.

Johnson said only the executive branch, not the courts, is equipped to make military battlefield targeting decisions about who qualifies as an enemy.

The courts in habeas cases, such as those involving whether a detainee should be released from the Guantanamo Bay detention facility in Cuba, make the determination of who can be considered an enemy combatant.

Late last year, a judge threw out a lawsuit filed by al-Awlaki's father, saying that the courts do not have the authority to review military decisions by the president aimed at protecting the country from terrorists. The cleric's father, Nasser al-Awlaki of Yemen, was suing to prevent the U.S. from targeting his son.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20111201/ap_on_go_ca_st_pe/us_targeted_killing

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Is Herman Cain Dropping Out? Mixed Signals From Campaign (ABC News)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/167762565?client_source=feed&format=rss

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